Background: As an acute phase protein, α1-antitrypsin (AAT) has been extensively studied in acute coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP).The purpose of the present study was to investigate the association between AAT plasma levels and SAP.Methods: Overall, 103 SAP patients diagnosed by coronary angiography and clinical manifestations and 118 control subjects matched for age and gender were enrolled in this case-control study.
Plasma levels of AAT, high-sensitivity C-reactive protein (hsCRP), lipid profiles and other clinical parameters were assayed for all participants.The severity of coronary lesions was evaluated based on the Gensini score (GS) assessed by coronary angiography.Results: Positively correlated with the GS (r = 0.
564, P < 0.001), the plasma AAT level in the SAP group was significantly higher than that in the control group (142.08 footjoy weste herren ± 19.
61 mg/dl vs.125.50 ± 19.
67 mg/dl, P < 0.001).The plasma AAT level was an independent predictor for both SAP (odds ratio [OR] = 1.
037, 95% confidence interval [CI]: 1.020-1.054, P < 0.
001) and a high GS (OR = 1.087, 95% CI: 1.051-1.
124, P < 0.001) in a multivariate logistic regression model.In the receiver operating characteristic curve analysis, plasma AAT level was found to have a larger area under the curve (AUC) for predicting a high GS (AUC = 0.
858, 95% CI: 0.788-0.929, P < 0.
001) beetroot birkenstock than that of hsCRP (AUC = 0.665, 95% CI: 0.557-0.
773, P = 0.006; Z = 2.9363, P < 0.
001), with an optimal cut-off value of 137.85 mg/dl (sensitivity: 94.3%, specificity: 68.
2%).Conclusions: Plasma AAT levels correlate with both the presence and severity of coronary stenosis in patients with SAP, suggesting that it could be a potential predictive marker of severe stenosis in SAP patients.